Hethuwen lacks the components she needs for a thorough study of the contents of a strange delivery from Hasta.
'Well, let us examine these strange specimens. In order to fully study these samples you brought, I will need some components for my experiment.
'The Orcs here in the Foundations of Stone are infected with a terrible disease; bring me a suitable sample of the fungus that consumes them. The Fanged Pit, north of here in Durin's Way, is home to a luminescent form of crystal that can often be found chipped off of greater pieces of jutting stone. Bring me one of these samples -- but beware the beast Riptalon when you are there! Lastly, the most vicious grodbog species found in the Redhorn Lodes have a rare strain of venom. You must bring me one of their venom sacs.
'Return to me once you've acquired these key materials and I will see if I can get to the bottom of Hasta's mystery.'
The infected Orcs can be found south of the Shadowed Refuge. Crystal fragments can be found in the Fanged Pit, in Durin's Way, to the north-east. Venomous gredbyg can be found in the Redhorn Lodes, west of the Shadowed Refuge.
Hethuwen has asked you bring her a fungal sample from the Orcs in the Foundations of Stone, a crystal from the Fanged Pit, and a venom sac from one of the vicious gredbyg in the Redhorn Lodes.
The Shadowed Refuge can be found in the Foundations of Stone, in the south-east reaches of Moria.
You should return with the gathered samples to Hethuwen at the Shadowed Refuge.